The Australian International School opened on 1 February 1993 at its original campus on Mount Sophia, an area behind Plaza Singapura and the Cathay Building reconstruction. The School started under the leadership of Miss Coral Dixon with 32 students and seven teachers, with no air-conditioning, uniform or facilities that are now taken for granted. By the end of the first year, the school roll exceeded 200.

The school experienced rapid growth with numbers having doubled after another year. The campus moved to Emerald Hill, directly behind Orchard Road. Although larger and able to accommodate many more students, it did not have a full-sized gym, pool, theatre or other much needed facilities.

Again, the school expanded out of its space and at the end of 1997 moved to Ulu Pandan, near Clementi; the former site of the Singapore American School, which had recently moved to a new site at Woodlands.

After a further five and a half years, the school finally secured land to construct a purpose built campus at Lorong Chuan, the current site, with Mr Peter Bond as Principal.

AIS was purchased by the Cognita Group in 2007. In 2008, a Junior School and Preschool  were constructed to house children from Preschool to Year 2 at an outstanding purpose-built facility with a bright, airy, contemporary building with large pod spaces for group work. In 2010, a new Senior building opened to accommodate Year 10, 11 and 12 students. This wing incorporates private study spaces, 35 classrooms and a new Science and Technology area.

In January 2012, Dr Nick Miller took over as Principal of AIS, and the School moved to a new school structure with two sub schools: Elementary School and Secondary School.

Mr Andre Casson was appointed Principal in November 2014 and has been instrumental in executing significant transformative changes that have led to improved academic outcomes for Secondary students at AIS. In July 2016, Mr Simon Leslie joined AIS in the newly created role of Head of School. From 2018, Mr Casson has moved  into the role of Head of School following Simon Leslie's retirement at the end of the 2017 academic year. Dr Edward Groughan, our current Principal took over in July 2017.

The opening of the Early Learning Village in July 2017 was a big step in th School's history, with the building being a world-leading purpose-built facility for our littlest learners, aged 18 months to 6 years old.